The day will see 16 more games spread across four venues. When all is said and done Friday night, we'll be left with 32 teams left with another chance at making it past the first weekend and into the Sweet 16.
Friday's winners will play again Sunday. Game times and TV info will likely be released late Friday night or early Saturday morning.
Here's a look at Friday's games. Scores will be added as games go final.
11:15 a.m.: Midwest Region; Philadelphia No. 2 Duke vs. No. 15 Albany CBS/Kevin Harlan, Len Elmore, Reggie Miller and Lewis Johnson
11:40 a.m.: West Region; Kansas City No. 5 Wisconsin vs. No. 12 Mississippi truTV/Marv Albert, Steve Kerr and Craig Sager
12:40 p.m.: East Region; Dayton, Ohio No. 8 N.C. State vs. No 9. Temple TBS/Jim Nantz, Clark Kellogg and Tracy Wolfson