Police said they found the cocaine hidden underground on four banana plantations in Antioquia.
Colombian President Juan Manuel Santos said the estimated value of the seized cocaine is $360 million U.S. dollars. And he linked the massive stash to the Gulf Clan, Colombia's largest drug-trafficking ring.
The bust comes as the United Nations continues to voice concerns about cocaine production in Colombia.
Earlier this year, a report from the U.N.'s Office on Drugs and Crimes found the country's coca cultivation areas increased by more than 50 percent from 2015 to 2016. Coca is used to make cocaine.
The report also said Colombia had the potential to produce an estimated 955 tons of cocaine last year.
But the U.N. is looking to reverse that trend. It recently signed an agreement to help the Colombian government reduce illicit crops like coca.