U.S. Route 27 has reopened from Interstate 75/Alligator Alley in Broward County and State Route 80 & Southern Boulevard in Palm Beach County.
Drivers are still urged to slow down and use caution.
The fire affected 3,000 acres, officials said Sunday.
A dense smoke advisory has been issued for inland Palm Beach County until 10 a.m. Monday. Smoke from a large wildfire in Broward County is creating poor visibility in inland Palm Beach County.
The smoke could affect the area for the next two days.