(CNN) -- Children should get vaccinated against preventable and potentially deadly diseases. Period.
That's what a review of more than 20,000 scientific studies on childhood vaccines concludes this week. The review appears in the latest edition of the medical journal Pediatrics.
The evidence strongly suggests that side effects from vaccines are incredibly rare, the study authors said. They found no ties between vaccines and the rising number of children with autism, as a small but vocal group of anti-vaccine activists, including actors Jenny McCarthy and Jim Carey, have said.
The review also found no link between vaccines and childhood leukemia, something that was suggested in earlier studies.
The researchers found that some vaccines did cause a few adverse effects but it was only for a tiny fraction of the population.
There was evidence that the meningococcal vaccine can lead to anaphylaxis -- a severe, whole-body allergic reaction -- in children allergic to ingredients in the vaccine. A study of the polio vaccine found that children with atopic dermatitis and a family history of allergies did have a higher chance of developing sensitivity to food allergens. Other studies found the MMR vaccine was linked to seizures.
"Vaccines, like any other medication, aren't 100% risk free," said Dr. Ari Brown an Austin, Texas-based pediatrician and author of the popular book "Baby 411," who was not involved with the study.
"You have a sore arm, redness at the injection site. Those are the things we see commonly. Fortunately the serious adverse effects is extremely rare."
Brown said parents ask her how safe vaccines are all the time. Some patients also ask if they should delay or stagger the vaccinations. She counsels against that practice. She said the younger the child, the more danger these diseases present.
"By delaying the vaccines you're putting your child at risk," Brown said.
The positive effects of vaccines dramatically outweigh the bad, experts said.
An editorial accompanying the study calls vaccines "one of the most successful public health achievements of the 20th century."
Because of vaccines, many diseases that plagued children for centuries have all but been eliminated.
"There were good reasons that these diseases were targeted for vaccine development since they are so life-threatening," said Dr. Carrie Byington, vice-chair for research in the University of Utah's pediatrics department, and the new chair for the American Academy of Pediatrics committee on infectious diseases.
Millions of Americans live longer on average because of the protection vaccines provide. Life expectancy has gone up in the United States by more than 30 years. Infant mortality decreased from 100 deaths per 1000 to 7 between the 1900s and 2000.
A vaccine for smallpox led the Centers for Disease Control and Prevention to declare the disease eradicated in 1978. Prior to a vaccination for diphtheria, it was one of the most common causes of illness and death among children. Now it is rarely reported in the United States.
Yet research shows there is still doubt among some medical residents about the effectiveness of vaccinations.
"That is particularly concerning for me," Byington said. "Young residents may be in the same position as young parents who have trained at a time, or lived at a time, when these diseases were extremely rare, and they may not have ever seen how serious a vaccine-preventable infection can be."
An increasing number of parents over the years have opted out of getting their children vaccinated. And that may be having a negative impact on the community's health.
A study found that large clusters of children who had not been vaccinated were close to the large clusters of whooping cough cases in the 2010 California epidemic. While California typically has higher vaccination rates than the rest of the country, that state is dealing with yet another whooping cough epidemic.
This spring also saw an 18-year high number of measles cases in the United States. The largest outbreak was in Ohio where the virus spread quickly among the Amish, who are mostly unvaccinated. This outbreak was a real surprise to health officials who thought that the infectious disease was thought to have been eliminated from the United States in 2000.
The editorial accompanying this latest study suggests doctors, who parents typically trust to tell the truth about medical information, need to use this study to speak with confidence about the importance of vaccinating children.
"Looking at all these mounds of data -- there is still no data that show an association that shows vaccine and autism," said Brown. "I would love it to close this chapter and move on. I don't think it will. But the more research, the more we learns about autism, the more we can reassure parents that there are no links here."
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CDC vaccine info: http://www.cdc.gov/vaccinesafety